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By: Q. Ingvar, M.B. B.CH., M.B.B.Ch., Ph.D.

Medical Instructor, University of Maryland School of Medicine

Testing Poor Vision the patient unable to read the largest ("20/200") letter on a Snellen chart should be moved closer to the chart until that letter can be read medicine man dr dre celexa 20 mg online. Visual acuity of "5/200" means that the patient can identify correctly the largest letter from a distance of 5 ft but not further away symptoms 89 nissan pickup pcv valve bad 10mg celexa with mastercard. Visual Field Testing Visual field testing should be included in every complete ophthalmologic examination because even dense visual field abnormalities may not be apparent to the patient symptoms low blood pressure buy celexa without prescription. Since the visual fields of the two eyes overlap 400 medications cheap celexa 20mg visa, for diagnostic purposes, each eye must be tested separately. Binocular visual field testing is useful in assessment of functional vision (see Chapter 25). Presentation of targets at a distance halfway between the patient and the examiner allows direct comparison of the field of vision of each eye of the patient and the examiner. Since the patient and examiner are staring eye to eye, any loss of fixation by the patient will be noticed. The patient must identify the number of fingers flashed while maintaining straight-ahead fixation. The upper and lower temporal and the upper and lower nasal quadrants are all tested in this fashion for each eye. A 5-mm-diameter red sphere or disk attached to a handle as the target allows detection and quantification of more subtle visual field defects, particularly if areas of abnormal reduction in color (desaturation) are sought. In disease of the right cerebral hemisphere, particularly involving the parietal lobe, there may be visual neglect (visual inattention) in which there is no comparable visual field loss on testing of each eye separately, but objects are not identified in the left hemifield of either eye if objects are simultaneously presented in the right hemifield. The patient, with both eyes open, is asked to signify on which side (right, left, or both) the examiner is intermittently wiggling his or her fingers. The patient will still be able to detect the fingers in the left hemifield when wiggled alone but not when the fingers in the right hemifield are wiggled simultaneously. More sophisticated means of visual field testing, important for detection of subtle visual field loss, such as in the diagnosis of early glaucoma and for quantification of any visual field defect, are discussed later in this chapter. Pupillary abnormalities may be due to (1) neurologic disease, (2) intraocular inflammation causing either spasm of the pupillary sphincter or adhesions of the iris to the lens (posterior synechiae), (3) markedly raised intraocular pressure causing atony of the pupillary sphincter, (4) prior surgical alteration, (5) the effect of systemic or eye medications, and (6) benign variations of normal. Dim lighting conditions help to accentuate the pupillary response and may best demonstrate an abnormally small pupil. Likewise, an abnormally large pupil may be more apparent in brighter background illumination. The consensual response is the normal simultaneous constriction of the opposite nonilluminated pupil. Swinging Penlight Test for Relative Afferent Pupillary Defect As a light is swung back and forth in front of the two pupils, one can compare the reactions to stimulation of each eye, which should be equal. If the neural response to stimulation of the left eye is impaired, the pupil response in both eyes will be reduced on stimulation of the left eye compared to stimulation of the right eye. As the light is swung from the right to the left eye, both pupils will begin to dilate normally as the light is moved away from the right eye and then not constrict or paradoxically widen as the light is shone into the left eye (since the direct response in the left eye and the consensual response in the right eye are reduced compared to the consensual response in the left eye and direct response in the right eye from stimulation of the right eye). When the light is swung back to the right eye, both pupils will begin to dilate as the light is moved away from the left eye and then constrict normally as the light is shone into the right eye. Importantly, it does not occur in media opacities such as corneal disease, cataract, and vitreous hemorrhage. Because the pupils are normal in size and may appear to react normally when each is stimulated alone, the swinging flashlight test is the only means of demonstrating a relative afferent pupillary defect. Also, because the pupils react equally, detection of a relative afferent pupillary defect requires inspection of only one pupil and can still be achieved when one pupil is structurally damaged or cannot be visualized, as in dense corneal opacity. Relative afferent pupillary defect is further discussed and illustrated in Chapter 14. A more complete discussion of ocular motility testing and eye movement abnormalities is presented in Chapters 12 and 14. Since each eye generates a visual image separate from and independent of that of the other eye, the brain must be able to fuse the two images in order to avoid "double vision. A simple test of binocular alignment is performed by having the patient look toward a penlight held several feet away. A pinpoint light reflection, or "reflex," should appear on each cornea and should be centered over each pupil if the two eyes are straight in their alignment. If the eye positions are convergent, such that one eye points inward ("esotropia"), the light reflex will appear temporal to the pupil in that eye.

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Since the retinal vessels all arise from the disk treatment high blood pressure discount celexa 10mg with visa, the latter is located by following any major vascular branch back to this common origin treatment diverticulitis generic celexa 20 mg free shipping. The width of the central cup divided by the width of the disk is the "cup-to-disk ratio treatment quotes images cheap celexa 20mg fast delivery. The normal disk tissue is compressed into a peripheral thin rim surrounding a huge pale cup symptoms ectopic pregnancy purchase celexa 20 mg online. This is surrounded by a more darkly pigmented and poorly circumscribed area called the foveola. The retinal vascular branches approach from all sides but stop short of the foveola. Thus, its location can be confirmed by the focal absence of retinal vessels or by asking the patient to stare directly into the light. They are examined and followed as far distally as possible in each of the four quadrants (superior, inferior, temporal, and nasal). The veins are darker and wider than their paired arteries (anatomically arterioles). The vessels are examined for color, tortuosity, and caliber, as well as for associated abnormalities, such as aneurysms, hemorrhages, or exudates. The green "redfree" filter assists in the examination of the retinal vasculature and the subtle striations of the nerve fiber layer as they course toward the disk (see Chapter 14). To examine the retinal periphery, which is greatly enhanced by dilating the pupil, the patient is asked to look in the direction of the quadrant to be examined. Thus, the temporal retina of the right eye is seen when the patient looks to the right, while the superior retina is seen when the patient looks up. Since it requires wide pupillary dilation and is difficult to learn, this technique is used primarily by ophthalmologists. As with direct ophthalmoscopy, the patient is told to look in the direction of the quadrant being examined. Using the preset head-mounted ophthalmoscope lenses, the examiner can then "focus on" and visualize this midair image of the retina. Comparison of Indirect & Direct Ophthalmoscopy Indirect ophthalmoscopy is so called because one is viewing an "image" of the retina formed by a hand-held "condensing lens. Thus, it presents a wide panoramic fundus view from which specific areas can be selectively studied under higher magnification using either the direct ophthalmoscope or the slitlamp with special auxiliary lenses. Comparison of view within the same fundus using the indirect ophthalmoscope (A) and the direct ophthalmoscope (B). One is the brighter light source that permits much better visualization through cloudy media. A second advantage is that by using both eyes, the examiner enjoys a stereoscopic view, allowing visualization of elevated masses or retinal detachment in three dimensions. Finally, indirect ophthalmoscopy can be used to examine the entire retina, even out to its extreme periphery, the ora serrata. Optical distortions caused by looking through the peripheral lens and cornea interfere very little with the indirect ophthalmoscopic examination compared with the direct ophthalmoscope. A smooth, thin metal probe is used to gently indent the globe externally through the lids at a point just behind the corneoscleral junction (limbus). By depressing around the entire circumference, the peripheral retina can be viewed in its entirety. Diagrammatic representation of indirect ophthalmoscopy with scleral depression to examine the far peripheral retina. Indentation of the sclera through the lids brings the peripheral edge of the retina into visual alignment with the dilated pupil, the hand-held condensing lens, and the head-mounted ophthalmoscope. Because of all of these advantages, indirect ophthalmoscopy is used preoperatively and intraoperatively in the evaluation and surgical repair of retinal detachments. A general medical examination would often include many of these same testing techniques.

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Onset at the opening snap ("middiastolic") with presystolic accentuation if in sinus rhythm medications neuropathy cheapest celexa. Rarely medicine 2015 lyrics trusted 20mg celexa, short diastolic (Graham Steell) murmur along the lower left sternal border medications vertigo celexa 20 mg for sale. May be associated with a lowpitched middiastolic murmur at the apex (Austin Flint) treatment nausea celexa 40 mg free shipping. Occurs in the setting of aortic stenosis, aortic regurgitation, and aortic root dilatation. Most often due to mitral valve prolapse; may not be associated with a systolic murmur. Additional diastolic sounds: Opening snap: A high-frequency, early diastolic sound most frequently caused by mitral stenosis. Pericardial knock: A low-frequency sound due to abrupt termination of ventricular filling in early diastole in the setting of constrictive pericarditis. The differential diagnosis of axis deviations (in order of likelihood) is outlined in Table 3. Lead V1: P wave has a terminal deflection that is 40 msec by 1 mm (one small box by one small box). Second R wave (R) in right precordial leads, with R greater than the initial R (look for "rabbit ears" in V1 and V2). Exercise myocardial O2 demand and unmasks coronary flow reserve in patients with hemodynamically significant coronary stenoses. False positives are more common in women and in those with atypical chest pain, no chest pain, and anemia. A noninvasive ultrasound imaging modality used to identify anatomic abnormalities of the heart and great vessels; to assess the size and function of cardiac chambers; and to evaluate valvular function. Resting regional left ventricular wall motion abnormalities (hypokinesis, akinesis) are highly suggestive of ischemic heart disease but can be seen in nonischemic dilated cardiomyopathy. The distribution of wall motion abnormalities suggests the culprit coronary artery. Stress echocardiography: Used to determine regional wall motion abnormalities in patients with a relatively normal resting echocardiogram and signs or symptoms of ischemic heart disease. Contraindications for using dobutamine include uncontrolled hypertension or recent clinically significant arrhythmia. Very useful for detecting stenotic or regurgitant blood flow across the valves as well as any abnormal communications within the heart. Cardiac output and pressure gradient data can be used to calculate stenotic valve areas. Bubble study: Injection of agitated normal saline to diagnose right-to-left shunts. Consider patent foramen ovale if bubbles flow directly from the right to the left atrium; consider intrapulmonary shunt with delayed appearance of bubbles in the left atrium. Common indications include the detection of left atrial thrombi, valvular vegetations, and thoracic aortic dissection. Redistribution images can be performed after 24 hours to look for additional areas of viable myocardium. It is also per- 95 formed to assess the severity of disease and guide further therapy. Drug-eluting stents the incidence of restenosis with the use of antiproliferative agents. Especially acute pulmonary edema, unless catheterization can be performed with the patient sitting up. Mortality for patients with left main coronary artery disease is > 10 times greater than that of patients with one- or two-vessel disease. Patients with renal insufficiency, insulin-requiring diabetes, advanced cerebrovascular and/or peripheral vascular disease, or severe pulmonary insufficiency have an incidence of death and other major complications from cardiac catheterization. Abrupt closure (< 1% with stenting): Of all cases, 75% occur within minutes of angioplasty and 25% within 24 hours.

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If you zoom in on the dorsal root ganglion symptoms tonsillitis generic celexa 40 mg amex, you can see smaller satellite glial cells surrounding the large cell bodies of the sensory neurons medicine technology purchase celexa 10 mg without prescription. This is analogous to the dorsal root ganglion treatment hepatitis c buy generic celexa 40mg online, except that it is associated with a cranial nerve instead of a spinal nerve treatment quadriceps tendonitis purchase generic celexa pills. The roots of cranial nerves are within the cranium, whereas the ganglia are outside the skull. For example, the trigeminal ganglion is superficial to the temporal bone whereas its associated nerve is attached to the mid-pons region of the brain stem. The neurons of cranial nerve ganglia are also unipolar in shape with associated satellite cells. The other major category of ganglia are those of the autonomic nervous system, which is divided into the sympathetic and parasympathetic nervous systems. The sympathetic chain ganglia constitute a row of ganglia along the vertebral column that receive central input from the lateral horn of the thoracic and upper lumbar spinal cord. Superior to the chain ganglia are three paravertebral ganglia in the cervical region. Three other autonomic ganglia that are related to the sympathetic chain are the prevertebral ganglia, which are located outside of the chain but have similar functions. They are referred to as prevertebral because they are anterior to the vertebral column. The neurons of these autonomic ganglia are multipolar in shape, with dendrites radiating out around the cell body where synapses from the spinal cord neurons are made. The neurons of the chain, paravertebral, and prevertebral ganglia then project to organs in the head and neck, thoracic, abdominal, and pelvic cavities to regulate the sympathetic aspect of homeostatic mechanisms. Another group of autonomic ganglia are the terminal ganglia that receive input from cranial nerves or sacral spinal nerves and are responsible for regulating the parasympathetic aspect of homeostatic mechanisms. These two sets of ganglia, sympathetic and parasympathetic, often project to the same organs-one input from the chain ganglia and one input from a terminal ganglion-to regulate the overall function of an organ. For example, the heart receives two inputs such as these; one increases heart rate, and the other decreases it. The terminal ganglia that receive input from cranial nerves are found in the head and neck, as well as the thoracic and upper abdominal cavities, whereas the terminal ganglia that receive sacral input are in the lower abdominal and pelvic cavities. Terminal ganglia below the head and neck are often incorporated into the wall of the target organ as a plexus. This can apply to nervous tissue (as in this instance) or structures containing blood vessels (such as a choroid plexus). For example, the enteric plexus is the extensive network of axons and neurons in the wall of the small and large intestines. The enteric plexus is actually part of the enteric nervous system, along with the gastric plexuses and the esophageal plexus. These structures in the periphery are different than the central counterpart, called a tract. They have connective tissues invested in their structure, as well as blood vessels supplying the tissues with nourishment. The outer surface of a nerve is a surrounding layer of fibrous connective tissue called the epineurium. Within the nerve, axons are further bundled into fascicles, which are each surrounded by their own layer of fibrous connective tissue called perineurium. Finally, individual axons are surrounded by loose connective tissue called the endoneurium (Figure 13. With what structures in a skeletal muscle are the endoneurium, perineurium, and epineurium comparable Cranial Nerves the nerves attached to the brain are the cranial nerves, which are primarily responsible for the sensory and motor functions of the head and neck (one of these nerves targets organs in the thoracic and abdominal cavities as part of the parasympathetic nervous system). They can be classified as sensory nerves, motor nerves, or a combination of both, meaning that the axons in these nerves originate out of sensory ganglia external to the cranium or motor nuclei within the brain stem. Three of the nerves are solely composed of sensory fibers; five are strictly motor; and the remaining four are mixed nerves. Learning the cranial nerves is a tradition in anatomy courses, and students have always used mnemonic devices to remember the nerve names.

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A survey of how different drugs affect autonomic function illustrates the role that the neurotransmitters and hormones play in autonomic function symptoms 10 weeks pregnant purchase genuine celexa line. Drugs can be thought of as chemical tools to effect changes in the system with some precision symptoms 6 weeks cheap celexa generic, based on where those drugs are effective treatment vaginal yeast infection order generic celexa online. Nicotine is not a drug that is used therapeutically denivit intensive treatment buy celexa 10 mg line, except for smoking cessation. When it is introduced into the body via products, it has broad effects on the autonomic system. Nicotine carries a risk for cardiovascular disease because of these broad effects. The drug stimulates both sympathetic and parasympathetic ganglia at the preganglionic fiber synapse. For most organ systems in the body, the competing input from the two postganglionic fibers will essentially cancel each other out. Because there is essentially no parasympathetic influence on blood pressure for the entire body, the sympathetic input is increased by nicotine, causing an increase in blood pressure. Also, the influence that the autonomic system has on the heart is not the same as for other systems. Other organs have smooth muscle or glandular tissue that is activated or inhibited by the autonomic system. The contradictory signals do not just cancel each other out, they alter the regularity of the heart rate and can cause arrhythmias. The sympathetic system is affected by drugs that mimic the actions of adrenergic molecules (norepinephrine and epinephrine) and are called sympathomimetic drugs. Drugs such as phenylephrine bind to the adrenergic receptors and stimulate target organs just as sympathetic activity would. Other drugs are sympatholytic because they block adrenergic activity and cancel the sympathetic influence on the target organ. Drugs that act on the parasympathetic system also work by either enhancing the postganglionic signal or blocking it. Anticholinergic drugs block muscarinic receptors, suppressing parasympathetic interaction with the organ. When someone is said to have a rush of adrenaline, the image of bungee jumpers or skydivers usually comes to mind. As described in this video, the nervous system has a way to deal with threats and stress that is separate from the conscious control of the somatic nervous system. The system comes from a time when threats were about survival, but in the modern age, these responses become part of stress and anxiety. What other organ system gets involved, and what part of the brain coordinates the two systems for the entire response, including epinephrine (adrenaline) and cortisol As shown in this short animation, pupils will constrict to limit the amount of light falling on the retina under bright lighting conditions. On the basis of what you have already studied about autonomic function, which effect would you expect to be associated with parasympathetic, rather than sympathetic, activity As discussed in this video, movies that are shot in 3-D can cause motion sickness, which elicits the autonomic symptoms of 3. The disconnection between the strokespell) to learn about a teenager who experiences a perceived motion on the screen and the lack of any change series of spells that suggest a stroke. In the end, sitting close to the screen or right in the middle of the theater one expert, one question, and a simple blood pressure cuff makes motion sickness during a 3-D movie worse Why would the heart have to beat faster when the teenager changes his body position from lying down to sitting, and then to standing Which signaling molecule is most likely responsible for an increase in digestive activity Which nerve projects to the hypothalamus to indicate the level of light stimuli in the retina What central fiber tract connects forebrain and brain is not part of both the somatic and autonomic systems Which type of drug would be an antidote to atropine flight responses in effectors A target effector, such as the heart, receives input from on these autonomic functions

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